Henry Ou, M.D., M.A.
Henry Ou is Associate Professor of Pediatric Otolaryngology-Head and Neck Surgery at Seattle Children's Hospital and the University of Washington, having joined the faculty in 2006. He did his residency training at the University of Washington followed by pediatric otolaryngology fellowship training at Seattle Children's Hospital, and is currently the Director of the Seattle Children's Hospital Hearing Loss Clinic. In addition, he was appointed by the Governor to the State of Washington Board of Hearing and Speech in 2014. Dr. Ou has over 15 years of experience in hearing research, with a particular emphasis on the use of the zebrafish to study drug-induced hearing loss and is actively investigating the development of drugs to prevent hearing loss.
Undergraduate Education: Cornell University, 1989-1993
Medical School: Washington University in St. Louis, School of Medicine, 1993-1998
Internship: University of Washington - General Surgery, 1998-1999
Residency: University of Washington - Otolaryngology-HNS, 1999-2004
Fellowship: Seattle Children's Hospital - Pediatric Otolaryngology-HNS, 2004-2006
Board Certification: Otolaryngology-HNS, 2005
Memberships: Fellow, American College of Surgeons; Member, American Society of Pediatric Otolaryngology; Member, American Academy of Otolaryngology-HNS; Member, Association for Research in Otolaryngology; Member, Northwest Academy of Otolaryngology
Awards and honors
2014: Advising Medical Physician, State of Washington Board of Hearing and Speech, appointed by Governor Jay Inslee
2013: Director of Hearing Loss Clinic, Seattle Children's Hospital
2013: Associate Fellowship Director, Pediatric Otolaryngology Fellowship - Seattle Children's Hospital/University of Washington
2008: William Potsic Basic Science Research Award, 1st Prize, American Society of Pediatric Otolaryngology (Mentor of Resident: Lynn Chiu)
2007: University of Washington School of Medicine, Marian E. Smith Junior Faculty Research Award
Dr. Ou's clinical interests include most aspects of pediatric otolaryngology (e.g. tonsils/adenoids management, neck masses, pediatric airway), with a subspecialty focus on pediatric hearing loss, chronic ear disease, cholesteatoma and other middle ear surgery, and cochlear implantation.
Dr. Ou's research focuses on the use of the zebrafish lateral line to study mechanisms of drug-induced hearing loss. He also works on the identification and development of drugs to prevent hearing loss.
Walker B, Norton S, Phillips G, Christianson E, Horn D, Ou H. Comparison of MRI in pediatric cochlear implant recipients with and without retained magnet., Int. J. Pediatr. Otorhinolaryngol. 2018 Jun; 10944-49
Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW. Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death., J. Clin. Invest. 2016 Sep; 126(9):3556-66
Tang J, Qian Y, Li H, Kopecky BJ, Ding D, Ou HC, DeCook R, Chen X, Sun Z, Kobel M, Bao J. Canertinib induces ototoxicity in three preclinical models., Hear. Res. 2015 Oct; 32859-66
Thomas AJ, Wu P, Raible DW, Rubel EW, Simon JA, Ou HC. Identification of small molecule inhibitors of cisplatin-induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line., Otol. Neurotol. 2015 Mar; 36(3):519-25
The Ou Lab uses the zebrafish lateral line to screen for drugs that cause and prevent hair cell injury. Lateral line hair cells are structurally and physiologically similar to inner ear hair cells and thus can be used to efficiently study mechanisms of inner ear damage. the zebrafish allows us to perform rapid, live imaging of hair cell death. We are particularly interested in anti-cancer drug-induced hearing loss and are investigating how drugs interact to damage hearing.
Virginia Merrill Bloedel Hearing Research Center
Seattle, WA 98195