Clifford R. Hume, M.D., Ph.D.
Primary clinical office
Clifford R. Hume, M.D., Ph.D.
Biography
Dr. Hume is a UW associate professor of otolaryngology-head and neck surgery and a researcher at the Virginia Merrill Bloedel Hearing Research Center. Dr. Hume is a physician-scientist with a research interest in developing new therapies for hearing loss.
Dr. Hume received his Ph.D. in immunology and molecular biology at Cornell University, followed by a postdoctoral fellowship in neurobiology and behavior at Columbia University. He returned to Cornell University to complete an M.D. and then moved to Seattle for a residency in otolaryngology-head and neck surgery at the University of Washington. In 2002, he joined the UW faculty as a surgeon-scientist and was promoted to associate professor in 2008.
He has clinical practices at the UW Medical Center, Harborview Medical Center, East Side Specialties Clinic, and the VA Puget Sound Medical Center. He runs a research program at UW and is an affiliate of the UW's Center on Human Development and Disability and the Institute for Stem Cell and Regenerative Medicine.
Overview
Undergraduate Education: Carleton College, Northfield, Minn., 1983
Medical School: Ph.D., Cornell University/Sloan Kettering Institute, New York, N.Y., 1989; M.D., Cornell University Medical College, New York, N.Y., 1996
Internship: University of Washington, 1997
Residency: University of Washington, 2002
Fellowship: Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 1989-1994
Board Certification: Otolaryngology-HNS, 2003
Memberships: American Academy of Otolaryngology, Head and Neck Surgery, Association for Research in Otolaryngology
Awards and honors
Helen Hay Whitney Foundation Biomedical Research Fellow
James Moore Scholarship. Department of Otolaryngology, Cornell University Medical College
American Neurotology Society, Herbert Silverstein Otology/Neurotology Research Award
Academic interests
CLINICAL INTERESTS
Dr. Hume specializes in medical and surgical management of diseases of the ear including hearing loss, tinnitus, ear infections, dizziness, and vertigo. He has expertise in middle ear surgery, cochlear implants, and bone-anchored hearing aids.
RESEARCH FOCUS
Hair cell regeneration, inner ear gene therapy, cochlear implants.
Recent Publications
Tong L, Strong MK, Kaur T, Juiz JM, Oesterle EC, Hume C, Warchol ME, Palmiter RD, Rubel EW. Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons., J. Neurosci. 2015 May; 35(20):7878-91
Atkinson PJ, Wise AK, Flynn BO, Nayagam BA, Hume CR, O'Leary SJ, Shepherd RK, Richardson RT. Neurotrophin gene therapy for sustained neural preservation after deafness., PLoS ONE 2012 ; 7(12):e52338
Golub JS, Tong L, Ngyuen TB, Hume CR, Palmiter RD, Rubel EW, Stone JS. Hair cell replacement in adult mouse utricles after targeted ablation of hair cells with diphtheria toxin., J. Neurosci. 2012 Oct; 32(43):15093-105
Lewis RM, Hume CR, Stone JS. Atoh1 expression and function during auditory hair cell regeneration in post-hatch chickens., Hear. Res. 2012 Jul; 289(1-2):74-85