David W. Raible, Ph.D.
David W. Raible, Ph.D., is the Virginia Merrill Bloedel Chair in Basic Hearing Science and professor in the Department of Otolaryngology - Head and Neck Surgery. He is also joint professor in the Department of Biological Structure and adjunct professor in the Departments of Biology and Genome Sciences. Dr. Raible received his B.A./B.S. degrees from Cornell University and his Ph.D. from the University of Pennsylvania with F. Arthur McMorris. He did postdoctoral training with Jonathan Raper at Penn and with Judith Eisen at the University of Oregon. He joined the faculty at the University of Washington as assistant professor in 1995 and was promoted to associate professor in 2001 and professor in 2006. He joined the department in 2021.
Awards and honors
Dr. Raible's lab investigates zebrafish as a model for hearing loss, for understanding hair cell development, death and regeneration.
Davis SN, Wu P, Camci ED, Simon JA, Rubel EW, Raible DW. Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity., Hear Res 2020 09; 395108019
Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP, Kros CJ. ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity., JCI Insight 2019 08; 4(15):
Lewis VM, Saunders LM, Larson TA, Bain EJ, Sturiale SL, Gur D, Chowdhury S, Flynn JD, Allen MC, Deheyn DD, Lee JC, Simon JA, Lippincott-Schwartz J, Raible DW, Parichy DM. Fate plasticity and reprogramming in genetically distinct populations of leucophores., Proc Natl Acad Sci U S A 2019 06; 116(24):11806-11811
Thomas ED, Raible DW. Distinct progenitor populations mediate regeneration in the zebrafish lateral line., Elife 2019 03; 8
Hair cells of the inner ear act as mechanosensors, converting mechanical stimuli to electrical signals transmitted to the brain. Hair cells of the auditory organs respond to sound stimuli for hearing perception; those in the vestibular organs respond to gravity and head movements for perception of balance. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cells are susceptible to environmental insults, including noise, chemical exposure, and accumulated damage during aging. Hair cell loss in humans is irreversible. Zebrafish lateral line hair cells share many properties with those of the inner ear and are sensitive to the same types of damaging agents as human cells. However, they are able to regenerate hair cells throughout life. The location of the lateral line on the surface of the body allows access for visualization and manipulation. We take an interdisciplinary approach to study hair cell development, death, and regeneration that uses genetics, genome editing, single cell profiling, high resolution imaging, small molecule screening, and computational modeling.
The Raible lab values equity and inclusion and strives to provide a welcoming environment for trainees from diverse backgrounds.